I am theoretical physicist by training. However, I early jumped into biology to study genome evolution and regulatory network structure in bacteria and I obtained a PhD in Bioinformatics form the University of Basel. During my postdoc training at the EPFL I worked on stochastic gene expression in single mammalian cells. Afterwards, I started my own research group at the University of Edinburgh and recently moved to the IGBMC.
The main research activity in my group is to develop stochastic and biophysical models of eukaryotic gene regulation. Our work lays at the interface between bioinformatics and biophysics combining tools and methods from both fields to develop mechanistic models of gene regulation based on both large-scale genome-wide data and single-cell imaging data. Some of our ongoing projects are:
- Transcription factor diffusion in a complex chromatin structure.
- Towards an integrative biophysical model of gene regulation to predict temporal patterns of RNA synthesis.
- Uncovering the underlying molecular mechanism of transcriptional bursting by live-cell imaging.